The Functional Role of Chloride Channels in Cardiac Pacemaker Activity
نویسندگان
چکیده
منابع مشابه
O23: Modulation of Pacemaker Channels and Rhythmic Thalamic Activity by Demyelination and Inflammatory Cytokines
The thalamus is a central element for the generation of rhythmic oscillatory activity under physiological and pathophysiological conditions. Especially slow oscillations in the delta and theta frequency band which normally occur during slow-wave sleep are associated with a number of neuropsychiatric conditions if they occur during wakefulness and may be the basis for the generation of character...
متن کاملEffect of endotoxemia on heart rate dynamics in rat isolated perfused hearts
Introduction: Beat-to-beat variation in heart rate shows a complex dynamics, and this complexity is changed during systemic inflammatory response syndrome (e.g. sepsis). It is not known whether or not cardiac pacemaker dynamical rhythm is affected by sepsis. The aim of this study was to investigate heart rate dynamics of isolated heart as well as expression of pacemaker channels (HCN) in a r...
متن کاملبررسی اثر مهار گیرنده رایانیدینی(RYR) بر فعالیت پیسمیکری
Background & Aim: The role of ryanodine receptor(RYR) on pacemaker activity of heart cells is controversial. Some investigators have suggested that it is obligatory, while others believe it is partial and not obligatory. The principle aim of this study was once more to characterize the role of ryanodine receptor(RyR) on the pacemaker activity of the sinoatrial node(SAN) and the atrioventric...
متن کاملFunctional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.
The spontaneous activity of pacemaker cells in the sino-atrial node (SAN) controls the heart rhythm and rate under physiological conditions. Pacemaker activity in SAN cells is due to the presence of the diastolic depolarization, a slow depolarization phase that drives the membrane voltage from the end of an action potential to the threshold of a new action potential. SAN cells express a wide ar...
متن کاملFunctional role of voltage gated Ca2+ channels in heart automaticity
Pacemaker activity of automatic cardiac myocytes controls the heartbeat in everyday life. Cardiac automaticity is under the control of several neurotransmitters and hormones and is constantly regulated by the autonomic nervous system to match the physiological needs of the organism. Several classes of ion channels and proteins involved in intracellular Ca(2+) dynamics contribute to pacemaker ac...
متن کامل